狙った獲物は必ず奪う神出鬼没の大泥棒・ルパン三世。彼はかの名高き怪盗ルパンの孫だ。
早撃ち0.3秒のクールなガンマン・次元大介、特異の斬鉄剣でどんなものでも真っ二つのサムライ・十三代石川五右衛門、謎の美女・峰不二子たちの仲間とともに、彼を捕まえるのを生きがいとしている警視庁の敏腕・銭形警部や、白乾児や摩毛狂介たちの暗黒街の強敵を相手にしながら、今日も華麗にお宝を頂戴するのだった。

Lupin the Third is an elusive master thief who always manages to snatch the loot he sets his sights on. He’s the grandson of Lupin, the gentleman thief.
With his companions—Daisuke Jigen, the cool gunman who can perform a quick 0.3-second draw, Goemon Ishikawa XIII, a samurai who can use his unique Zantetsuken sword to split anything in two, and Fujiko Mine, a mysterious and beautiful woman—he skillfully makes off with the day’s treasures while warding off the constant pursuit of Inspector Zenigata of the Tokyo Metropolitan Police, who has made it his life's mission to capture him, and facing formidable enemies from the underworld such as Pycal and Kyosuke Mamo.